DOUBLE STRIKE APPROACH FOR TUMOR ATTACK: ENGINEERING T CELLS USING A CD40L:CD28 CHIMERIC CO-STIMULATORY SWITCH PROTEIN FOR ENHANCED TUMOR TARGETING IN ADOPTIVE CELL THERAPY

Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity, tumor rejection and long-term T cell persistence.When using antigen-specific T cell receptors (TCR) instead of CARs, the lack of co-stimulatory signals hampers robust antitumoral response, hence limit

Numerous lithium-ion battery (LIB) fires and explosions have raised serious concerns about the safety issued associated with LIBs; some of these incidents were mainly caused by overcharging of LIBs.Therefore, to have a better understanding of the fire hazards caused by LIB overcharging, two widely used commercial LIBs, nickel manganese cobalt oxide

The combination of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) and intensive occupational therapy (iOT) has been shown to ameliorate upper limb hemiparesis in patients with chronic subcortical stroke.However, the neural mechanisms underlying its efficacy are poorly understood.Our aim was to examine the cortical reorganizati

The behaviour of fluid flow is a complex paradigm for cognitive interpretation and visualisation.Engineers need to visualise the behaviour mechanics Grip Sensor Wire of flow field response in order to enhance the cognitive ability in problem solving.Therefore, mixed reality related technology is the solution for enhanced virtual interactive learnin

Abstract Background Plasmodium falciparum malaria remains a major public health problem.A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose.However, there are increasing reports of poor quality anti-malarials in Africa.Methods Seven collections of